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Influencia de la microbiota en la asociación entre enfermedad periodontal y diabetes mellitus tipo 2 144
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mar 11, 2024
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El objetivo de esta revisión bibliográfica es analizar la evidencia existente sobre la relación de la microbiota oral con el establecimiento y progresión de enfermedad periodontal y diabetes. La microbiota es un ecosistema de microorganismos que se encuentran en nuestro organismo, donde aproximadamente más de 700 bacterias diferentes se encuentran en la cavidad bucal, y su disbiosis da inicio a características clínicas sumado con otros factores sistémicos y locales. En los últimos años se ha analizado la composición de la microbiota como firma biológica como estados de salud o enfermedad. La enfermedad periodontal se considera de origen multifactorial y su mecanismo etiopatogénico se basa en la disbiosis oral. La relación bidireccional de la periodontitis con pacientes de enfermedades endocrinas como la diabetes mellitus tipo 2 contribuye a perpetuar un estado inflamatorio que por consecuencia ocasiona la pérdida de tejidos periodontales de soporte.
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González-Rascón, A., Mejía-León, M., Loera Morales, P., Doñas Penilla, I., García Arévalo, F., & Fontes García, Z. (2024). Influencia de la microbiota en la asociación entre enfermedad periodontal y diabetes mellitus tipo 2. Revista Del Centro De Investigación De La Universidad La Salle, 16(61), 01-18. https://doi.org/10.26457/recein.v16i61.3536
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Gurung, M., Li, Z., You, H., Rodrigues, R., Jump, D. B., Morgun, A., & Shulzhenko, N. (2020). Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine, 51. https://doi.org/10.1016/j.ebiom.2019.11.051
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Janakiram, C., & Dye, B. A. (2020). A public health approach for prevention of periodontal disease. Periodontology 2000, 84(1), 202–214. https://doi.org/10.1111/prd.12337
Kasper, D. L., & Al, E. (2020). Harrison manual de medicina. Mcgraw Hill.
Kawai, T., & Akira, S. (2005). Arthritis Research & Therapy, 7(1), 12. https://doi.org/10.1186/ar1469
Kolenbrander, P. E., Andersen, R. N., Blehert, D. S., Egland, P. G., Foster, J. S., & Palmer, R. J. (2002). Communication among Oral Bacteria. Microbiology and Molecular Biology Reviews, 66(3), 486–505. https://doi.org/10.1128/mmbr.66.3.486-505.2002
Konkel, J. E., O’Boyle, C., & Krishnan, S. (2019). Distal Consequences of Oral Inflammation. Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.01403
Lalla, E., & Papapanou, P. N. (2011). Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nature reviews. Endocrinology, 7(12), 738–748. https://doi.org/10.1038/nrendo.2011.106
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Lang, N. P., & Bartold, P. M. (2018). Periodontal health. Journal of Clinical Periodontology, 45, S9–S16. https://doi.org/10.1111/jcpe.12936
Li, C., Li, B., Dong, Z., Gao, L., He, X., Liao, L., Hu, C., Wang, Q., & Jin, Y. (2014). Lipopolysaccharide differentially affects the osteogenic differentiation of periodontal ligament stem cells and bone marrow mesenchymal stem cells through Toll-like receptor 4 mediated nuclear factor κB pathway. Stem Cell Research & Therapy, 5(3). https://doi.org/10.1186/scrt456
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Mejía-León, M. E., & Calderón de la Barca, A. M. (2015). Diet, microbiota and immune system in type 1 diabetes development and evolution. Nutrients, 7(11), 9171-9184. https://doi.org/10.3390/nu7115461
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Blasco-Baque, V., Garidou, L., Pomié, C., Escoula, Q., Loubieres, P., Le Gall-David, S., Lemaitre, M., Nicolas, S., Klopp, P., Waget, A., Azalbert, V., Colom, A., Bonnaure-Mallet, M., Kemoun, P., Serino, M., & Burcelin, R. (2016). f induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response. Gut, 66(5), 872–885. https://doi.org/10.1136/gutjnl-2015-309897
Boles, A., Kandimalla, R., & Reddy, P. H. (2017). Dynamics of diabetes and obesity: Epidemiological perspective. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1863(5), 1026–1036. https://doi.org/10.1016/j.bbadis.2017.01.016
Curtis, M. A., Diaz, P. I., & Van Dyke, T. E. (2020). The role of the microbiota in periodontal disease. Periodontology 2000, 83(1), 14–25. https://doi.org/10.1111/prd.12296
Dirección General de Epidemiología (2020). Resultados del Sistema de Vigilancia Epidemiológica de Patologías Bucales SIVEPAB 2019 México. Gobierno de México. https://www.gob.mx/salud/documentos/informes-sivepab-2019
Flemming, H.-C., Wingender, J., Szewzyk, U., Steinberg, P., Rice, S. A., & Kjelleberg, S. (2016). Biofilms: an emergent form of bacterial life. Nature Reviews. Microbiology, 14(9), 563–575. https://doi.org/10.1038/nrmicro.2016.94
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020). Pathophysiology of type 2 diabetes mellitus. International Journal of Molecular Sciences, 21(17). https://doi.org/10.3390/ijms21176275
Graves, D. T., Liu, R., Alikhani, M., Al-Mashat, H., & Trackman, P. C. (2006). Diabetes-enhanced inflammation and apoptosis--impact on periodontal pathology. Journal of Dental Research, 85(1), 15–21. https://doi.org/10.1177/154405910608500103
Graves, D. T., Corrêa, J. D., & Silva, T. A. (2018). The Oral Microbiota Is Modified by Systemic Diseases. Journal of Dental Research, 98(2), 148–156. https://doi.org/10.1177/0022034518805739
Graziani, F., Gennai, S., Solini, A., & Petrini, M. (2017). A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes An update of the EFP-AAP review. Journal of Clinical Periodontology, 45(2), 167–187. https://doi.org/10.1111/jcpe.12837
Gurav, A. N. (2016). Management of diabolical diabetes mellitus and periodontitis nexus: Are we doing enough? World Journal of Diabetes, 7(4), 50-66. https://doi.org/10.4239/wjd.v7.i4.50
Gurung, M., Li, Z., You, H., Rodrigues, R., Jump, D. B., Morgun, A., & Shulzhenko, N. (2020). Role of gut microbiota in type 2 diabetes pathophysiology. EBioMedicine, 51. https://doi.org/10.1016/j.ebiom.2019.11.051
Halim, M., & Halim, A. (2019). The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes). Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13(2), 1165–1172. https://doi.org/10.1016/j.dsx.2019.01.040
Instituto Mexicano del Seguro Social. (2018) Guía de práctica clínica GPC Diagnóstico y Tratamiento Farmacológico de la diabetes mellitus tipo 2 en el primer nivel de atención Evidencias y Recomendaciones Catálogo Maestro de Guías de Práctica Clínica: gpc-IMSS-718-18. https://www.imss.gob.mx/sites/all/statics/guiasclinicas/718GER.pdf
Janakiram, C., & Dye, B. A. (2020). A public health approach for prevention of periodontal disease. Periodontology 2000, 84(1), 202–214. https://doi.org/10.1111/prd.12337
Kasper, D. L., & Al, E. (2020). Harrison manual de medicina. Mcgraw Hill.
Kawai, T., & Akira, S. (2005). Arthritis Research & Therapy, 7(1), 12. https://doi.org/10.1186/ar1469
Kolenbrander, P. E., Andersen, R. N., Blehert, D. S., Egland, P. G., Foster, J. S., & Palmer, R. J. (2002). Communication among Oral Bacteria. Microbiology and Molecular Biology Reviews, 66(3), 486–505. https://doi.org/10.1128/mmbr.66.3.486-505.2002
Konkel, J. E., O’Boyle, C., & Krishnan, S. (2019). Distal Consequences of Oral Inflammation. Frontiers in Immunology, 10. https://doi.org/10.3389/fimmu.2019.01403
Lalla, E., & Papapanou, P. N. (2011). Diabetes mellitus and periodontitis: a tale of two common interrelated diseases. Nature reviews. Endocrinology, 7(12), 738–748. https://doi.org/10.1038/nrendo.2011.106
Lane, M., Howland, G., West, M., Hockey, M., Marx, W., Loughman, A., O’Hely, M., Jacka, F., & Rocks, T. (2020). The effect of ultra-processed very low-energy diets on gut microbiota and metabolic outcomes in individuals with obesity: A systematic literature review. Obesity Research & Clinical Practice, 14(3), 197–204. https://doi.org/10.1016/j.orcp.2020.04.006
Lang, N. P., & Bartold, P. M. (2018). Periodontal health. Journal of Clinical Periodontology, 45, S9–S16. https://doi.org/10.1111/jcpe.12936
Li, C., Li, B., Dong, Z., Gao, L., He, X., Liao, L., Hu, C., Wang, Q., & Jin, Y. (2014). Lipopolysaccharide differentially affects the osteogenic differentiation of periodontal ligament stem cells and bone marrow mesenchymal stem cells through Toll-like receptor 4 mediated nuclear factor κB pathway. Stem Cell Research & Therapy, 5(3). https://doi.org/10.1186/scrt456
Liccardo, D., Cannavo, A., Spagnuolo, G., Ferrara, N., Cittadini, A., Rengo, C., & Rengo, G. (2019). Periodontal Disease: A Risk Factor for Diabetes and Cardiovascular Disease. International Journal of Molecular Sciences, 20(6), 1414. https://doi.org/10.3390/ijms20061414
Li, Y., Qian, F., Cheng, X., Wang, D., Wang, Y., Pan, Y., Chen, L., Wang, W., & Tian, Y. (2023). Dysbiosis of Oral Microbiota and Metabolite Profiles Associated with Type 2 Diabetes Mellitus. Microbiology spectrum, 11(1), e0379622. https://doi.org/10.1128/spectrum.03796-22
Mejía-León, M. E., & Calderón de la Barca, A. M. (2015). Diet, microbiota and immune system in type 1 diabetes development and evolution. Nutrients, 7(11), 9171-9184. https://doi.org/10.3390/nu7115461
Newman, M. G., Takei, H., Klokkevold, P. R., & Carranza, F. A. (2014). Periodontología clínica de Carranza. Amolca.
Omori, K., Ohira, T., Uchida, Y., Ayilavarapu, S., Batista, E. L., Yagi, M., Iwata, T., Liu, H., Hasturk, H., Kantarci, A., & Van Dyke, T. E. (2008). Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase. Journal of Leukocyte Biology, 84(1), 292–301. https://doi.org/10.1189/jlb.1207832
Papapanou, P. N., Sanz, M., Buduneli, N., Dietrich, T., Feres, M., Fine, D. H., Flemmig, T. F., Garcia, R., Giannobile, W. V., Graziani, F., Greenwell, H., Herrera, D., Kao, R. T., Kebschull, M., Kinane, D. F., Kirkwood, K. L., Kocher, T., Kornman, K. S., Kumar, P. S., & Loos, B. G. (2018). Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions. Journal of Periodontology, 89, S173–S182. https://doi.org/10.1002/jper.17-0721
Peterson, C. T., Sharma, V., Elmén, L., & Peterson, S. N. (2015). Immune homeostasis, dysbiosis and therapeutic modulation of the gut microbiota. Clinical & Experimental Immunology, 179(3), 363–377. https://doi.org/10.1111/cei.12474
Pirih, F. Q., Monajemzadeh, S., Singh, N., Sinacola, R. S., Shin, J. M., Chen, T., Fenno, J. C., Kamarajan, P., Rickard, A. H., Travan, S., Paster, B. J., & Kapila, Y. (2021). Association between metabolic syndrome and periodontitis: The role of lipids, inflammatory cytokines, altered host response, and the microbiome. Periodontology 2000, 87(1), 50–75. https://doi.org/10.1111/prd.12379
Polak, D., Sanui, T., Nishimura, F., & Shapira, L. (2020). Diabetes as a risk factor for periodontal disease—plausible mechanisms. Periodontology 2000, 83(1), 46–58. https://doi.org/10.1111/prd.12298
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