the Hologenomics and its relationship to cancer1290 Hologenomics and Cancer

Abstract

A holobiont is considered a biological entity associated in symbiosis with microorganisms that complement its metabolic pathways, physiological functions and genetic variation. The term hologenome refers to the entire genetic content of the holobiont, i.e. the sum of the host's genome, its organelles along with the microbial genomes that comprise it. It has now been established that there is a relationship between disease development and the human microbiome, so this review will describe the role of the hologenome in cancer and the parallel mass sequencing techniques applied in hologenomics. The study of hologenomics together with sequencing and bionformatics technologies will provide relevant information for the development of new diagnostic tools and their subsequent application in clinical practice.