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COVID-19: pathophysiology and therapeuthic proposals in clinical research
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Abstract
The COVID-19 pandemic declared by the World Health Organization on March 11, 2020, has currently caused 6,287,771 cases and 379,941 deaths worldwide. About 80% of people infected with SARS-CoV-2 are asymptomatic, the rest develop COVID-19 disease. Factors such as age, sex, and coexistence of comorbidities such as hypertension, diabetes, and cardiovascular and respiratory system diseases increase the severity of the disease. When SARS-CoV-2 infection reaches the lower respiratory tract, the immune response is accompanied by intense secretion of cytokines and chemokines, leading to edema and loss of function of the alveolar-capillary unit that added to the cytokine storm it gives rise to multiple organic failure. This review describes the pathophysiology related to the clinical manifestations of COVID-19 and presents the main drugs studied in clinical trials.
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