Apis mellifera and miRNAs: natural model of longevity and a hologenomic perspective of aging Natural model of longevity and a hologenomic perspective of aging

Abstract

Longevity of an organism is favored when there is homeostasis between the host and its intestinal microbiota. There are few foods with the ability to extend the life span of an organism, Royal Jelly (RJ) in bee Apis mellifera is one of them. Nutriepigenetic potential of RJ is found in protein components, fatty acids, metabolites and microRNAs (miRNAs) that it contains and that make an important nutraceutical. In this review we address a hologenomic approach to the aging and longevity process, emphasizing the use of miRNAs contained in the RJ and the possible modulation that these could have on the intestinal microbiota.